Can the kidney repair itself?

Although a damaged kidney usually cannot be repaired on its own, the condition can be treated if caught early. Acute renal failure can be reversed with immediate hospitalization, although the recovery process can take weeks or months and requires regular monitoring, dietary modifications and medications. Contrary to long-held beliefs, a new study shows that kidneys have the ability to regenerate themselves, Shutterstock. Acute renal failure requires immediate treatment.

The good news is that acute kidney failure can often be reversed. The kidneys usually start working again several weeks or months after the underlying cause has been treated. If your kidneys fail completely, the only treatment options available are dialysis for the rest of your life or a transplant. These renal analogs derived from HMSCs can be further developed by combining with systems to “grow the kidney in situ” .68 If you develop acute kidney failure, prompt treatment and hospitalization may cause your kidneys to work again.

If the initial problem that caused kidney failure resolves and the kidneys are not severely damaged, they may begin to heal on their own. However, in people with acute renal failure, kidney failure develops rapidly within a few hours or a few days. In some cases, damaged kidneys can be fully restored in structure and function3, indicating the remarkable regenerative capacity of the kidney after acute ischemic injury. It was thought that kidney cells did not reproduce much once the organ was fully formed, but new research shows that the kidneys are regenerating and repairing themselves throughout life.

The complexity of the morphological structure of the kidney and the evidence of the existence of populations of different progenitor cells led to the suggestion that different parts of the kidney may have several groups of progenitor cells. Scientists seeking to regenerate damaged kidneys have found that blocked kidneys in newborns have a remarkable ability to repair themselves after the obstruction is removed. However, they did express Pax2, housed in kidneys that were damaged by intramuscular injection of glycerol, and gave rise to endothelial and tubular epithelial cells within these kidneys. Conversely, if the renal structure is totally altered, which could occur in patients with end-stage renal damage undergoing long-term dialysis, the only cure could be the development of a functioning complete kidney de novo.

The kidney has the potential to regenerate itself as long as the damage is not too severe and the structure of the kidney remains intact. A decrease in kidney function that occurs over a longer period of time is called chronic kidney failure. Human embryonic metanephroi and human embryonic metanephroi seven to eight weeks of age experienced remarkable growth and produced highly differentiated renal structures, suggesting that the embryonic kidney contains renal progenitor cells with the ability to generate many types of cells. Because of the anatomical complexity of the kidney and the need for residential cells to communicate with each other to produce urine, the artificial renal structure must include glomeruli, tubules, interstices and vessels.

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